Ivacaftor restores delayed mucociliary transport caused by Pseudomonas aeruginosa –induced acquired cystic fibrosis transmembrane conductance regulator dysfunction in rabbit nasal epithelia

ConclusionIn rabbit nasal epithelium, ivacaftor robustly stimulates CFTR-mediated Cl− secretion and normalizes ASL and CBF in PAO1-induced acquired CFTR dysfunction. Preclinical testing of CFTR potentiators as therapy forP aeruginosa rabbit sinusitis is planned.

Source: International Forum of Allergy and Rhinology - October 27, 2021 Category: Allergy & Immunology Authors: Do ‐Yeon Cho, Shaoyan Zhang, Daniel F. Skinner, Dong Jin Lim, Catherine Banks, Jessica W. Grayson, Guillermo J. Tearney, Steven M. Rowe, Bradford A. Woodworth Tags: ORIGINAL ARTICLE Source Type: research