Impact of High DosE rAdioTherapy (HEAT) in Localized Prostate Cancer: An Individual Patient Data (IPD) Meta-Analysis of 15 Randomized Trials

CONCLUSION: Dose-escalation alone does not improve MFS or OS. In the presence of STADT or LTADT, the impact of dose-escalation differed when pooling non-randomized comparisons (which is prone to selection bias) versus performing an NMA restricted to only direct randomized comparisons (which is affected by limited network connectivity). BCR was more consistently improved. Given the uncertain impact on survival and the potential for increased toxicity, future studies using biomarker selection are needed to better personalize which patients benefit most from dose escalation.PMID:34700632 | DOI:10.1016/j.ijrobp.2021.07.190

Source: Ann Oncol - October 27, 2021 Category: Cancer & Oncology Authors: A U Kishan T Romero X Wang T M Pisansky M Roach M Bolla A Steigler J W Denham W U Shipley H M Sandler F Y Feng D J Joseph J G Armstrong M Dunne S Malone S Roy A Zapatero Y Sun J M Michalski D E Spratt Source Type: research