Differential hyperpolarization to substance P and calcitonin gene ‐related peptide in smooth muscle versus endothelium of mouse mesenteric artery

ConclusionsCalcitonin gene-related peptide elicits greater hyperpolarization than substance P. Substance P hyperpolarizes both cell layers through KCa channels and involves endothelium-derived NO in smooth muscle. Endothelial hyperpolarization to CGRP requires KCa channels, while KATP channels mediate hyperpolarization in smooth muscle. Differential K+ channel activation in smooth muscle and endothelium through sensory neurotransmission may selectively tune mesenteric blood flow.

Source: Microcirculation - October 23, 2021 Category: Research Authors: Charles E. Norton, Erika M. Boerman, Steven S. Segal Tags: ORIGINAL ARTICLE Source Type: research