Possible selection bias limits the interpretation of single-cell transcriptomics data of steroid-resistant asthma exacerbation [Biological Sciences]

We believe there are a few shortcomings in the study design and data interpretation in the research article by Wang et al. (1). These include 1) cell selection bias, 2) cytokine selection bias from single-cell transcriptomics (SCT) data, and 3) lack of a lipopolysaccharide+dexamethasone (LPS+DEX) control group in the mouse...

http://www.pnas.org/content/118/43/e2102858118.short?rss=1

Source: Proceedings of the National Academy of Sciences - October 22, 2021 Category: Science Authors: Joytri Dutta, Rakhshinda Rehman, Shamsudheen K. Vellarikkal, Laura E. Fredenburgh, Ulaganathan Mabalirajan Tags: Letters, Immunology and Inflammation Source Type: research