Inter-species cortical registration between macaques and humans using a functional network property under a spherical demons framework

by Haewon Nam, Chongwon Pae, Jinseok Eo, Maeng-Keun Oh, Hae-Jeong Park Systematic evaluation of cortical differences between humans and macaques calls for inter-species registration of the cortex that matches homologous regions across species. For establishing homology across brains, structural landmarks and biological features have been used without paying sufficien t attention to functional homology. The present study aimed to determine functional homology between the human and macaque cortices, defined in terms of functional network properties, by proposing an iterative functional network-based registration scheme using surface-based spherical demons. The fun ctional connectivity matrix of resting-state functional magnetic resonance imaging (rs-fMRI) among cortical parcellations was iteratively calculated for humans and macaques. From the functional connectivity matrix, the functional network properties such as principal network components were derived t o estimate a deformation field between the human and macaque cortices. The iterative registration procedure updates the parcellation map of macaques, corresponding to the human connectome project’s multimodal parcellation atlas, which was used to derive the macaque’s functional connectivity matr ix. To test the plausibility of the functional network-based registration, we compared cortical registration using structural versus functional features in terms of cortical regional areal change. We also evaluated the interhe...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research