Cancers, Vol. 13, Pages 5290: REV1 Inhibition Enhances Radioresistance and Autophagy

This study reports a lack of radiosensitization in response to REV1 inhibition by small molecule inhibitors in ionizing radiation-exposed cancer cells. Instead, REV1 inhibition unexpectedly triggers autophagy, which is a known biomarker of radioresistance. We report a possible role of the REV1 TLS protein in determining cancer treatment outcomes depending upon the type of DNA damage inflicted. Furthermore, we discover that REV1 inhibition directly triggers autophagy, an uncharacterized REV1 phenotype, with a significant bearing on cancer treatment regimens.

Source: Cancers - October 21, 2021 Category: Cancer & Oncology Authors: Kanayo E. Ikeh Erica N. Lamkin Andrew Crompton Jamie Deutsch Kira J. Fisher Mark Gray David J. Argyle Won Y. Lim Dmitry M. Korzhnev M. Kyle Hadden Jiyong Hong Pei Zhou Nimrat Chatterjee Tags: Article Source Type: research