Dynamical Systems Modeling of Early-Term Immune Reconstitution with Different Anti-Thymocyte Globulin (ATG) Administration Schedules in Allogeneic Stem Cell Transplantation.

Adequate immune reconstitution following allogeneic hematopoietic cell transplantation (HCT) is critical to optimize clinical outcomes, particularly relapse, infection and graft versus host disease (GVHD). Recovery of adaptive immunity is crucial, as it represents the critical mechanism of protection against a variety of viral and fungal pathogens, as well as ensure relapse protection in the long run. Therefore, early T cell reconstitution is crucial to the long-term success of HCT. This is because of the versatility provided by the T cell receptor mediated identification of a wide variety of pathogen and tumor associated epitopes.

Source: Biology of Blood and Marrow Transplantation - October 21, 2021 Category: Hematology Authors: Viktoriya Zelikson, Gary Simmons, Natasha Raman, Elizabeth Krieger, Anatevka Rebiero, Kelly Hawks, May Aziz, Catherine Roberts, Alden Chesney, Jason Reed, Ronald Gress, Amir Toor Source Type: research