Cancers, Vol. 13, Pages 5275: Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe3O4@Cu2 –xS for Photothermal Cancer Cell Killing

In this study, the nanoparticles of Fe3O4@Cu2–xS were rendered positively charged by conjugating their surfaces with different functional groups for strong electrostatic binding onto the negatively-charged cancer cells. In addition to the positively charged surfaces, the Fe3O4@Cu2–xS nanoparticles were also modified with folic acid (FA) for biomarker-based cell targeting. The dual-targeting approach synergistically utilizes the effectiveness of both charge- and biomarker-based cell binding for enhanced cell targeting. Further, these superparamagnetic Fe3O4@Cu2–xS nanoparticles exhibit much stronger IR absorptions compared to Fe3O4, therefore much more effective in photothermal therapy.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research

Related Links:

The capacity of T cells to recognize and mount an immune response against tumor antigens depends on the large diversity of the T-cell receptor (TCR) repertoire generated in the thymus during the process of T-cell development. However, this process is dramatically impaired by immunological insults, such as that caused by cytoreductive cancer therapies and infections, and by the physiological decline of thymic function with age. Defective thymic function and a skewed TCR repertoire can have significant clinical consequences. The presence of an adequate pool of T cells capable of recognizing specific tumor antigens is a prere...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: The above-combined results revealed the anticancer effect of CVLME, which may be due to the selective induction of ROS in breast carcinoma.
Source: Indian Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
-liang Ye Folate-aminocaproic acid-doxorubicin (FA-AMA-hyd-DOX) was firstly synthesized by our group. It was indicated that FA-AMA-hyd-DOX was pH-responsive, and had strong cytotoxicity on a folate receptor overexpressing cell line (KB cells) in vitro. The aim of our study was to further explore the potential use of FA-AMA-hyd-DOX as a new therapeutic drug for breast cancer. The cellular uptake and the antiproliferative activity of the FA-AMA-hyd-DOX in MDA-MB-231 cells were measured. Compared with DOX, FA-AMA-hyd-DOX exhibited higher targeting ability and cytotoxicity to FR-positive tumor cells. Subsequently, the tiss...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
AbstractPurpose of ReviewTo review the neurologic complications of systemic anti-cancer therapies and radiation therapy.Recent FindingsAlthough many of the newer systemic therapies have more favorable side effect profiles than traditional cytotoxic chemotherapy, neurotoxicity has been seen with some of newer targeted therapies, immunotherapy, and T cell engaging therapies, including CAR-T therapy. The most recent advances in radiation-induced neurotoxicity have focused on the prevention and the management of cognitive dysfunction, a known long-term complication of brain irradiation.SummaryCancer therapies can damage both t...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
Chem. Commun., 2021,57,12417-12435 DOI: 10.1039/D1CC04846E, Feature ArticleXuelu He, Zhenqi Jiang, Ozioma Udochukwu Akakuru, Juan Li, Aiguo Wu The controlled synthesis methods and the applications of nanoscale covalent organic frameworks in cancer therapy are summarized in this feature article. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
CONCLUSIONS: Taken together, better understanding of REG3A may lead to new insights that make it a potentially useful target for cancer therapy.PMID:34811636 | DOI:10.1007/s11033-021-06904-x
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Source Type: research
Acta Pharmacol Sin. 2021 Nov 22. doi: 10.1038/s41401-021-00800-7. Online ahead of print.ABSTRACTXanthine oxidoreductase (XOR) is a critical, rate-limiting enzyme that controls the last two steps of purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid. It also produces reactive oxygen species (ROS) during the catalytic process. The enzyme is generally recognized as a drug target for the therapy of gout and hyperuricemia. The catalytic products uric acid and ROS act as antioxidants or oxidants, respectively, and are involved in pro/anti-inflammatory actions, which are associated with various dis...
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Source Type: research
Acta Pharmacol Sin. 2021 Nov 22. doi: 10.1038/s41401-021-00796-0. Online ahead of print.ABSTRACTCyclin-dependent kinase (CDK) 9 associates mainly with cyclin T1 and forms the positive transcription elongation factor b (p-TEFb) complex responsible for transcriptional regulation. It has been shown that CDK9 modulates the expression and activity of oncogenes, such as MYC and murine double minute 4 (MDM4), and it also plays an important role in development and/or maintenance of the malignant cell phenotype. Malfunction of CDK9 is frequently observed in numerous cancers. Recent studies have highlighted the function of CDK9 thro...
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Source Type: research
Contributors : Izabela Zarczynska ; Monika Gorska-Arcisz ; Alexander J Cortez ; Katarzyna A Kujawa ; Agata M Wilk ; Andrzej C Skladanowski ; Aleksandra Stanczak ; Monika Skupinska ; Maciej Wieczorek ; Katarzyna M Lisowska ; Rafal Sadej ; Kamila KitowskaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFGFR signalling is one of the most prominent pathways involved in cell growth and development, as well as cancer progression. FGFR1 amplification occurs in approximately 20% of all squamous cell lung carcinomas (SCC) - one of the most common subtypes of non-small cell lung carcinoma (NSCLC...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Izabela Zarczynska ; Monika Gorska-Arcisz ; Alexander J Cortez ; Katarzyna A Kujawa ; Agata M Wilk ; Andrzej C Skladanowski ; Aleksandra Stanczak ; Monika Skupinska ; Maciej Wieczorek ; Katarzyna M Lisowska ; Rafal Sadej ; Kamila KitowskaSeries Type : Genome variation profiling by genome tiling arrayOrganism : Homo sapiensFGFR signalling is one of the most prominent pathways involved in cell growth and development, as well as cancer progression. FGFR1 amplification occurs in approximately 20% of all squamous cell lung carcinomas (SCC) - one of the most common subtypes of non-small cell lung carcinoma (NSCLC)...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome variation profiling by genome tiling array Homo sapiens Source Type: research
More News: Cancer | Cancer & Oncology | Cancer Therapy | Folic Acid | Nanotechnology | Study | Vitamin B9