Reconsolidation Therapy With Propranolol as a Treatment for Chronic Pain

Conditions:   Chronic Low-back Pain;   Fibromyalgia Interventions:   Drug: Propranolol Hydrochloride;   Drug: Placebo;   Behavioral: Reactivation procedure;   Behavioral: Pain neuroscience education Sponsor:   Université de Sherbrooke Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Introduction: Fibromyalgia is a debilitating syndrome characterized by diffuse and chronic musculoskeletal pain and tender points in muscles and soft tissues. Studies have suggested that this dysfunction may cause deterioration of respiratory functions.Objective: We performed a systematic review and meta-analysis of case-control studies to explore the respiratory disturbances among persons with fibromyalgia in comparison with healthy adults.Methods: We systematically searched seven electronic databases: MEDLINE/PubMed, Web of Science, Scopus, Science Direct, Pedro database, CINAHL, and Cochrane Library for articles publish...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical problems Source Type: research
Purpose: Fibromyalgia is a chronic pain condition. The National Institute for Health and Care Excellence Chronic Pain Guideline Scope states that “there has been little change in the prevalence and time course of chronic pain despite significant scientific advances to improve understanding of the neurobiology of pain”. In chronic conditions, there is a massive role for self-management. One method to encourage better self-management and se lf-care are disease-specific community-run support groups.
Source: Physiotherapy - Category: Physiotherapy Authors: Tags: P175 Source Type: research
Purpose: Fibromyalgia (FM) is a complex long-term condition affecting up to 5.4% of the UK population. It is associated with chronic widespread pain, fatigue, stiffness, sleep problems, memory and concentration difficulties, and irritable bowel syndrome. FM can cause high levels of disability, with individuals making frequent use of healthcare resources, and experiencing loss of workdays. Current guidelines for the treatment of FM all recommend non-pharmacological interventions, of which cognitive behaviour therapy (CBT), aerobic exercise, warm water therapy, relaxation and patient education are the best evidenced.
Source: Physiotherapy - Category: Physiotherapy Authors: Tags: O056 Source Type: research
AbstractNociplastic pain is defined as pain due to sensitization of the nervous system, without a sufficient underlying anatomical abnormality to explain the severity of pain. Nociplastic pain may be manifest in various organ systems, is often perceived as being more widespread rather than localized and is commonly associated with central nervous system symptoms of fatigue, difficulties with cognition and sleep, and other somatic symptoms; all features that contribute to considerable suffering. Exemplified by fibromyalgia, nociplastic conditions also include chronic visceral pain, chronic headaches and facial pain, and chr...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Clin Exp Rheumatol. 2021 Nov 18. Online ahead of print.ABSTRACTOBJECTIVES: Fibromyalgia (FM) is a prevalent disabling condition characterised by chronic widespread pain. It is considered a complex illness in which the prognosis is conditioned by affective and cognitive mediators still largely unknown in FM. To investigate the correlation between psychological variables (acceptance, negative affect, and mindfulness) and functional disability or physical impact, anxiety/depression symptoms and emotional distress, and also to evaluate the mediating role of acceptance and mindfulness between negative affect, physical impact, a...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Authors: Source Type: research
Conclusion: Fibromyalgia patients are particularly prone to suicide, in terms of ideation, attempt, risk and events, warranting a pre-emptive screening of their mental health status. Given the few studies available, the high amount of heterogeneity, the evidence of publications bias and the lack of statistical significance when adjusting for underlying psychiatric co-morbidities, further high-quality studies should be conducted.Clinical Trial Registration:ClinicalTrial.gov, identifier 10.17605/OSF.IO/Y4BUE.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Discussion: Avoidance and persistence activity patterns are shown as multidimensional constructs but not pacing. The ongoing pain in these women may make it difficult to regulate their activity taking into account other goals not contingent on pain fluctuations.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
This article aims to examine the causes, diagnosis, and current treatment protocols of FM, as well as discuss some continuing debates and diagnostic challenges which physicians face in accurately diagnosing fibromyalgia.PMID:34786265 | PMC:PMC8580749 | DOI:10.7759/cureus.18692
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
CONCLUSIONS AND RELEVANCE: This review highlights the importance of considering the components of occupational adaptation while caring for people with FM. What This Article Adds: This systematic review identifies the factors influencing the occupational adaptation of people living with FM and emphasizes the importance of addressing those factors.PMID:34780617 | DOI:10.5014/ajot.2021.047134
Source: The American Journal of Occupational Therapy - Category: Occupational Health Authors: Source Type: research
Repetitive transcranial magnetic stimulation of the motor cortex (M1-rTMS) is a non-invasive therapy for chronic pain 101, including fibromyalgia syndrome (FMS) 56,75. Compared to a sham treatment, 2 weeks of daily active M1-rTMS relieves clinical pain, reduces fatigue, increases daily functioning, and improves sleep quality 104. Weekly, bi-weekly, and monthly treatments further increase daily functioning and quality-of-life (QoL) for 3-6 months 21,91. Therefore, M1-rTMS offers a potentially long-term benefit for FMS patients 46,67,68,75,91,101.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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