Trends in uptake of Pap test in Estonia: results from cross-sectional studies in 2004 –2020

AbstractBackgroundIn 2006, Estonia started organized nationwide cervical cancer (CC) screening program, but in 2020 incidence of CC in was still second highest in Europe. An estimated 80% of women have done Pap tests outside the organized screening program. The aim of this study was (1) to describe the trend in lifetime uptake of Pap test and (2) to explore trends in lifetime uptake of Pap test by age group, nationality and education among 25-64-years-old women in Estonia based on data from 2004 to 2020.MethodsData of 6685 women aged 25-64 years who participated in population-based cross-sectional surveys of Health Behavior among Estonian Adult Population in 2004-2020 was analyzed. Uptake of Pap test was determined by asking women whether they have ever had a Pap test. The proportion of women who reported taking a Pap test was calculated for each study year. Chi-square test for trend was used to evaluate statistically significant changes (p
Source: The European Journal of Public Health - Category: General Medicine Source Type: research

Related Links:

In this study, paclitaxel (PTX)-loaded pH-responsive niosomes modified with ergosterol were developed. This new formulation was characterized in terms of size, morphology, encapsulation efficiency (EE), and in vitro release at pH 5.2 and 7.4. The in vitro efficacy of free PTX and niosome/PTX was assessed using MCF7, Hela, and HUVEC cell lines. In order to evaluate the in vivo efficacy of niosomal PTX in rats as compared to free PTX, the animals were intraperitoneally administered with 2.5 mg/kg and 5 mg/kg niosomal PTX for two weeks. Results showed that the pH-responsive niosomes had a nanometric size, spherical morphology...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
To qualitatively and quantitatively analyze needle visibility in combined intracavitary and interstitial cervical cancer brachytherapy on 3D transrectal ultrasound (TRUS) in comparison to gold standard MRI.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Vaccine. 2021 Nov 29:S0264-410X(21)01486-9. doi: 10.1016/j.vaccine.2021.11.041. Online ahead of print.ABSTRACTHPV vaccination of adolescent girls is the most effective measure to prevent cervical cancer. The World Health Organization recommends that adolescent girls receive two doses of vaccine but only a small proportion of girls from regions with the highest disease burden are vaccinated because of cost and logistical considerations. Our Costa Rica HPV Vaccine trial suggested that one dose of the bivalent HPV vaccine provides robust and lasting protection against persistent HPV infections for over a decade. Data from a p...
Source: Vaccine - Category: Allergy & Immunology Authors: Source Type: research
Comput Math Methods Med. 2021 Nov 23;2021:6350038. doi: 10.1155/2021/6350038. eCollection 2021.ABSTRACTThe main characteristics of cervical cancer are abnormal and uncontrolled cell proliferation, and it regulates cell growth, differentiation, and cell death through genetic and epigenetic changes. This paper mainly discusses the radiosensitivity of the cervical cancer protein kinase B signaling pathway and discusses the specific mechanisms that affect the occurrence and development of cervical cancer. In addition, this paper studies the effect of transient transfection knocking down the expression of TRIP4 in cervical canc...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Authors: Source Type: research
CONCLUSIONS: CASC9-1 exerted influences on various biological behaviors of cervical SCC cells via targeting miR-383-5p to up-regulate MAPKAP1. All these results mirrored that CASC9-1 might be a potential target for cervical SCC treatment.PMID:34857398 | DOI:10.1016/j.arcmed.2021.10.008
Source: Cell Research - Category: Cytology Authors: Source Type: research
Vaccine. 2021 Nov 29:S0264-410X(21)01486-9. doi: 10.1016/j.vaccine.2021.11.041. Online ahead of print.ABSTRACTHPV vaccination of adolescent girls is the most effective measure to prevent cervical cancer. The World Health Organization recommends that adolescent girls receive two doses of vaccine but only a small proportion of girls from regions with the highest disease burden are vaccinated because of cost and logistical considerations. Our Costa Rica HPV Vaccine trial suggested that one dose of the bivalent HPV vaccine provides robust and lasting protection against persistent HPV infections for over a decade. Data from a p...
Source: Vaccine - Category: Allergy & Immunology Authors: Source Type: research
Acta Histochem. 2021 Nov 30;124(1):151821. doi: 10.1016/j.acthis.2021.151821. Online ahead of print.ABSTRACTThe identification of the best reference gene is a critical step to evaluate the relative change in mRNA expression of a target gene by RT-qPCR. In this work, we evaluated nineteen genes of different functional classes using Real Time Human Reference Gene Panel (Roche Applied Sciences), to identify the internal housekeeping genes (HKGs) most suitable for gene expression normalization data in human cell lines. Normal cell lines CCD-19LU (lung fibroblast), HEK-293 (epithelial cell of embryonic kidney), WI-26 VA4 (lung ...
Source: Acta Histochemica - Category: Biochemistry Authors: Source Type: research
J Bioinform Comput Biol. 2021 Dec 3:2150031. doi: 10.1142/S0219720021500311. Online ahead of print.ABSTRACTWith the rapid development of deep sequencing technologies, a large amount of high-throughput data has been available for studying the carcinogenic mechanism at the molecular level. It has been widely accepted that the development and progression of cancer are regulated by modules/pathways rather than individual genes. The investigation of identifying cancer-related active modules has received an extensive attention. In this paper, we put forward an identification method ModFinder by integrating both biological networ...
Source: Journal of Bioinformatics and Computational Biology - Category: Bioinformatics Authors: Source Type: research
In conclusion, this study enhances our understanding of HPV-induced carcinogenesis in PSCC, which may not only rely on the E6/E7 oncogenes, but mat also affect the expression of critical genes and thus activate oncogenic pathways.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
tsuo Naoyuki Miyasaka We evaluated oncologic outcomes of laparoscopic radical hysterectomy using the no-look no-touch technique (NLNT). We analyzed patients with early stage (IA2, IB1, and IIA1, FIGO2008) cervical cancer treated between December 2014 and December 2019. The primary endpoint was disease-free survival (DFS). We compared the outcomes of the abdominal radical hysterectomy (ARH) and NLNT groups using a Cox model with inverse probability of treatment weighting (IPTW), according to propensity scores. We also evaluated NLNT’s non-inferiority to ARH using an evaluation of heterogeneity between the re...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
More News: Cancer | Cancer & Oncology | Cervical Cancer | Education | Estonia Health | General Medicine | International Medicine & Public Health | Statistics | Study | Universities & Medical Training | Women