Correlation of blood high mobility group box-1 protein with mortality of patients with sepsis: A meta-analysis

Sepsis, defined as a life-threatening organ dysfunction attributable to a dysregulated host response to infection,1 remains a major cause of death in the intensive care unit (ICU) and a critical consumer for medical resources around the world, along with its associated illnesses. According to a global study, there were an estimated 11.0 million incident cases of sepsis-related mortality worldwide in 2017, representing about 19.7% of all global deaths.2 To promptly identify sepsis patients at higher risks of mortality and optimize treatment options, such risk-stratified systems as Sequential Organ Failure Assessment (SOFA) and Physiology And Chronic Health Evaluation (APACHE) have been universally adopted at present.
Source: Heart and Lung - Category: Intensive Care Authors: Source Type: research