Better Way to Fight Breast Cancer That Has Spread to Brain

Scientists are reporting a first: They used an advanced ultrasound technique to help deliver the drug Herceptin to the patients' brain tumors.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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In conclusion, high TC2N expression is significantly correlated with poor overall survival of glioma patients via enhancing tumor growth.PMID:34840225 | DOI:10.1620/tjem.255.247
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Source Type: research
Clin J Oncol Nurs. 2021 Dec 1;25(6):23. doi: 10.1188/21.CJON.S2.23.ABSTRACTFor cognitive dysfunction, standards of care are based on established evidence-based practice. Cognitive dysfunction is the decline in function in one or more cognitive domains, including attention and concentration, executive function, information processing speed, language, visuospatial skill, psychomotor ability, and/or learning and memory. Cognitive dysfunction occurs in 80% of patients with brain tumors, 40% of patients with acute myeloid leukemia, and as many as 75% of patients with breast cancer.PMID:34800120 | DOI:10.1188/21.CJON.S2.23
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Source Type: research
ConclusionMYL9 can serve as a prognostic signature in pan-cancer and is associated with immune infiltration. This pan-cancer study is the first to show  a relatively comprehensive understanding of the prognostic and immunological roles of MYL9 across different cancers.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: SHORT REPORT Source Type: research
Drug Deliv Transl Res. 2021 Oct 30. doi: 10.1007/s13346-021-01039-9. Online ahead of print.ABSTRACTBrain metastases (BMs) are the most common type of brain tumor, and the incidence among breast cancer (BC) patients has been steadily increasing over the past two decades. Indeed, ~ 30% of all patients with metastatic BC will develop BMs, and due to few effective treatments, many will succumb to the disease within a year. Historically, patients with BMs have been largely excluded from clinical trials investigating systemic therapies including immunotherapies (ITs) due to limited brain penetration of systemically administered ...
Source: Cell Research - Category: Cytology Authors: Source Type: research
Int J Oncol. 2021 Nov;59(5):95. doi: 10.3892/ijo.2021.5275. Epub 2021 Oct 29.ABSTRACTRiluzole, a glutamate release inhibitor, has been in use for the treatment of amyotrophic lateral sclerosis for over two decades since its approval by the Food and Drug Administration. Recently, riluzole has been evaluated in cancer cells and indicated to block cell proliferation and/or induce cell death. Riluzole has been proven effective as an anti‑neoplastic drug in cancers of various tissue origins, including the skin, breast, pancreas, colon, liver, bone, brain, lung and nasopharynx. While cancer cells expressing glutamate receptors...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research
In this study, we evaluated whether the combination of focused ultrasound (FUS) and microbubbles can improve adoptively NK-92MI cell infiltration into ovarian tumors through biodistribution, immunofluorescence, and flow cytometry. The treatment effects of using this strategy twice a week were explored. The potential molecular mechanism of FUS assisting NK cell therapy was also initially explored through evaluating the expression of ICAM1 and CX3CL1 by qRT-PCR. Our results indicated that FUS and microbubbles can improve NK-92MI cells’ infiltration into tumors, and the combination of FUS and NK-92MI cells had a better ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Abstract As irreplaceable energy sources of minimally invasive treatment, light and sound have, separately, laid solid foundations in their clinic applications. Limited by relatively shallow penetration depth of light, traditional therapeutic modality of photodynamic therapy (PDT) usually involves superficial targets such as shallow seated skin conditions, head and neck cancers, eye disorders, early stage cancer of esophagus, etc. For ultrasound-driven sonodynamic therapy (SDT), however, accessibility to various organs is permitted by superior transmission and focusing ability of ultrasound in biological tissues, ...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Conclusion: The problem faced by the researchers during image denoising techniques and machine learning applications for clinical settings have also been discussed. PMID: 30532667 [PubMed]
Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
In this study, we examined the impact of focused ultrasound (FUS) in combination with microbubbles on the transport of two relevant chemotherapy-based anticancer agents in breast cancer brain metastases at...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
Most people think of ultrasound as an imaging modality. Yet, there are many other clinical uses for the high frequency soundwaves. Focused ultrasound waves can promote the opening of the blood-brain barrier, and they can be used to ablate fibroids, a...
Source: Medgadget - Category: Medical Devices Authors: Tags: Medicine News Source Type: blogs
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