Cancers, Vol. 13, Pages 5188: Basal Cell Carcinoma Treated with High Dose Rate (HDR) Brachytherapy —Early Evaluation of Clinical and Dermoscopic Patterns during Irradiation

Cancers, Vol. 13, Pages 5188: Basal Cell Carcinoma Treated with High Dose Rate (HDR) Brachytherapy—Early Evaluation of Clinical and Dermoscopic Patterns during Irradiation Cancers doi: 10.3390/cancers13205188 Authors: Tomasz Krzysztofiak Grażyna Kamińska-Winciorek Andrzej Tukiendorf Magdalena Suchorzepka Piotr Wojcieszek Basal cell carcinoma (BCC) is the most frequent malignancy of the Caucasian population. Dermoscopy is an established diagnostic method providing the bridge between clinical and pathological examination. Surface skin high dose rate (HDR) brachytherapy is an organ sparing treatment method used for non-surgical candidates. This prospective study aimed to observe clinical and dermoscopic features and their evolution in 23 patients with pathologically confirmed BCC that have been treated with HDR brachytherapy. In all cases, custom-made surface moulds were used. HDR brachytherapy was performed with 192Ir, dose 45Gy was delivered to the tumour in nine fractions of 5Gy, three times a week. The evolution of clinical and dermoscopic features was followed up at the beginning of treatment, and on the day of every fraction (t1–t9). Dermoscopic evaluation of neoplastic and non-neoplastic structures was based on current diagnostic criteria according to current literature. Univariate logistic regression showed a decreasing number of clinical and pathological features of basal cell carcinoma with every treatment fraction. The effect was more strongly pr...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research