Lower Urine Osmolality in Lithium Users Associated with Chronic Kidney Disease, Hypothyroidism, and Diabetes Mellitus: GSK-3β Inhibition as a Mechanism for Lithium-Associated Medical Illness?

Lithium is an essential mood disorder treatment. Unfortunately, lithium has been linked with several medical conditions, especially chronic kidney disease (CKD), although biological mechanisms are unknown. Glycogen synthase kinase3β inhibition (GSK3β), though, has been associated with low urine osmolality (UOsm) in lithium users and a broad variety of medical effects in other populations [1].

Source: Medical Hypotheses - March 6, 2015 Category: Biomedical Science Authors: Soham Rej, Marilyn Segal, Nancy C.P. Low, Istvan Mucsi, Christina Holcroft, Kenneth Shulman, Karl J. Looper Tags: Correspondence Source Type: research