Efficacy of Pregabalin and Antioxidants Combination in Reducing Pain in Chronic Pancreatitis: A Double Blind Randomized Trial

ConclusionThe combination of pregabalin and antioxidant significantly reduces the pain, requirement of non-opioid analgesics, and the number of hospital admissions in patients with CP. It also significantly improves the overall patient satisfaction.Clinical Trials Register NumberCTRI/2017/05/008492.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research

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CONCLUSION: Although patients with CP had similar calorie intake to controls, studies that analysed the contribution of alcohol to energy intake showed that patients with CP consumed fewer non-alcohol calories than healthy controls. A high calorie intake, made up to a large degree by alcohol, may in part contribute to poor nutritional status in CP.PMID:34629801 | PMC:PMC8473599 | DOI:10.3748/wjg.v27.i34.5775
Source: World Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
ConclusionsPatients who have systemic lupus erythematous with high disease activity have the potential to develop fatal complications due to pancreatitis, so appropriate treatments are required for such patients.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
This report investigates an unusual case of recurrent pancreatitis. A 22-year-old female was admitted to the emergency room for severe abdominal pain, nausea, and weight loss. She reported having these symptoms since she was a toddler. The clinician ordered fecal pancreatic elastase-1, fat-soluble vitamins, molecular studies, and imaging of the pancreas by computed tomography. The screening test result for fecal pancreatic elastase-1 revealed severe pancreatic exocrine insufficiency, and the concentrations of fat-soluble vitamins were also low. Imaging showed scattered calcifications in the pancreas. These findings support...
Source: Clinical Biochemistry - Category: Biochemistry Authors: Source Type: research
Am J Physiol Gastrointest Liver Physiol. 2021 Sep 15. doi: 10.1152/ajpgi.00482.2020. Online ahead of print.ABSTRACTChronic pancreatitis (CP) is a complex inflammatory disorder with numerous associated genetic and environmental risk factors. The most distressing characteristic of CP is recalcitrant pain, often requiring surgical resection including total pancreatectomy with islet autotransplantation (TPIAT). We studied 5 consented subjects undergoing pancreatic resection and processed isolated cells for single cell RNA sequencing (scRNA-Seq). Using high-dimensional transcriptomic cluster analysis we identified eleven unique...
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Source Type: research
Conditions:   Chronic Pancreatitis;   Pain Intervention:   Drug: Non-enteric coated pancreatic enzyme preparation Sponsor:   Asian Institute of Gastroenterology, India Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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