Subsequent liver transplantation did not reverse recurrence of oxalate nephropathy after isolated kidney transplantation for primary hyperoxaluria type 2

Asian J Surg. 2021 Oct 7:S1015-9584(21)00570-4. doi: 10.1016/j.asjsur.2021.08.066. Online ahead of print.ABSTRACTPrimary hyperoxaluria type 2 is a rare autosomal recessive genetic disease characterized by endogenous oxalate excess caused by deficiency of glyoxalate reductase/ hydroxypyruvate reductase. The optimal form of transplantation for primary hyperoxaluria type 2 remains controversial. Herein, we described a 26-year-old man with primary hyperoxaluria type 2 confirmed by genetic testing. The patient experienced rapid and severe recurrence of oxalate nephropathy after isolated kidney transplantation. Despite extensive fluid intake and the use of potassium citrate, the urine volume and estimated glomerular filtration rate decreased progressively. To avoid further accumulation of oxalate crystal in the graft and save the renal function, subsequent liver transplantation was performed. However, it failed to restore the function of the kidney allograft and the patient began hemodialysis afterwards. Subsequent liver transplantation after isolated kidney transplantation was not an optimal choice for patients with primary hyperoxaluria type 2. It seems combined liver-kidney transplantation or kidney transplantation after liver transplantation should be preferred.PMID:34629272 | DOI:10.1016/j.asjsur.2021.08.066
Source: Asian Journal of Surgery - Category: Surgery Authors: Source Type: research