Randomized control trial on peri ‐operative antibiotic prophylaxis in live liver donors – Are three doses enough?

AbstractDonor safety is paramount in live donor liver transplantation (LDLT)1. Live donor hepatectomy is a major surgery with an overall morbidity of 20% and major complications rate of about 4-5%1. Infective complications are the most common morbidity in live liver donors2-4. Hepatectomy being a clean contaminated surgery along with impaired glucose tolerance, long operating time and major blood loss, leads to recommended use of prophylactic peri-operative antibiotic for decreasing peri-operative surgical site infections and other infective complications5-6. Overuse of antibiotics, not just increases the cost, but also decreases the patient ’s innate immunity and gives rise to antibiotic resistance. Optimal duration of prophylactic antibiotic in live liver donor hepatectomy is unclear7-8. There are few randomized control trials on antibiotic prophylaxis in patients undergoing hepatectomy for other causes with contradictory results9-12 (table 4) but none in live liver donors (LLD). Current study is a single center double blind randomized control equivalence trial comparing efficacy of shorter duration (3 doses) of peri-operative antibiotics versus 9 doses in preventing infective complications after live liver donor hepatectomy.
Source: Journal of Hepato-Biliary-Pancreatic Surgery - Category: Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research