Polyethylene glycol and polysorbate testing in twelve patients prior to or after COVID-19 vaccine administration

Immediate allergic reactions compatible with anaphylaxis have been reported severalfold higher with the coronavirus 19 disease (COVID-19) vaccine than other vaccines. It is hypothesized that immunoglobulin E (IgE) mediated reactions to polyethylene glycol (PEG) 2000, an excipient in the mRNA vaccines (such as Pfizer and Moderna) used to stabilize the lipid nanoparticle, are responsible for reported COVID-19 vaccine reactions.1 COVID-19 vaccine-induced anaphylaxis has only been linked to PEG allergy in few patients to date2,3, with many more patients having allergic reactions, making other mechanisms more likely.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research