Impact of clinical characteristics of colonic diverticular bleeding in extremely elderly patients treated with direct oral anti-coagulant drugs: a retrospective multi-center study
J Clin Biochem Nutr. 2021 Sep;69(2):222-228. doi: 10.3164/jcbn.20-140. Epub 2021 Apr 3.ABSTRACTSince there were no available data about colonic diverticular bleeding in extremely elderly patients (>80 years old) treated with direct oral anticoagulants (DOACs), we tried to determine clinical characteristics in those with colonic diverticular bleeding taking DOACs and to compare clinical outcomes of those in DOAC-treated to those in warfarin-treated . We enrolled DOAC-treated (n = 20) and warfarin-treated (n = 23) extremely elderly patients with diverticular bleeding diagnosed by colonoscopy. We performed a retrospective review of patients' medical charts and endoscopic findings. We classified colonic diverticular bleeding based on endoscopic features due to modified previous study following three groups, type A (active bleeding), type B (non-active bleeding) and type C (bleeding suspected). Clinical outcomes such as number of recurrent bleeding, thrombotic events and mortality were estimated. There were no differences in endoscopical features and clinical characteristics between patients treated with DOAC and warfarin therapy. However, the number of recurrent bleeding, frequency of required blood transfusions and units of blood transfusion in warfarin-treated patients were significantly higher (p<0.05) compared to those in DOAC-treated groups. In addition, mortality and thrombotic events did not differ between DOAC- and warfarin-treated patients. Clinical outcomes sugges...
Source: Clinical Biochemistry - Category: Biochemistry Authors: Kumiko Kirita Yasuhiro Kodaka Yoshiaki Shibata Nobue Ueki Shuhei Agawa Hiroshi Yamawaki Ryota Niikura Nobutake Yamamichi Kentaro Izumi Mariko Hojo Kyohei Maruyama Takatsugu Yamamoto Katya Gudis Masanori Watanabe Mitsuru Kaise Katsuhiko Iwakiri Seiji Futag Source Type: research
More News: Biochemistry | Bleeding | Blood Transusion | Colonoscopy | Coumadin | Diverticular Disease | Study | Warfarin