The Effects of Parenteral Amino Acid Therapy on Protein Carbamylation in Maintenance Hemodialysis Patients

Protein carbamylation is a urea-driven post-translational protein modification associated with mortality in dialysis patients. Free amino acids (AAs) are competitive inhibitors of protein carbamylation and animal studies suggest increasing AA concentrations reduces carbamylation burden. We hypothesized that AA therapy in maintenance hemodialysis patients would reduce carbamylation, carrying the potential to improve clinical outcomes.

Source: Journal of Renal Nutrition - March 6, 2015 Category: Urology & Nephrology Authors: Sahir Kalim, Guillermo Ortiz, Caitlin A. Trottier, Joseph J. Deferio, S. Ananth Karumanchi, Ravi I. Thadhani, Anders H. Berg Tags: Research Brief Source Type: research