Measurable residual disease monitoring of SPAG6, ST18, PRAME, and XAGE1A expression in peripheral blood may detect imminent relapse in childhood acute myeloid leukemia

Overexpressed genes may be applicable for monitoring of measurable residual disease (MRD) in childhood acute myeloid leukemia (AML) patients without a leukemia-specific target. The normal expression of five leukemia-associated genes (SPAG6, ST18, MSLN, PRAME, XAGE1A) was defined in children without hematologic disease (n=53) and children with suspected infection (n=90). Gene expression at AML diagnosis (n=50) and during follow-up (n=21) was compared with child-specific reference values. At AML diagnosis, 34/50 children (68%) had high expression of at least one of the five genes, and so did 16/31 children (52%) without a leukemia-specific target.

Source: Journal of Molecular Diagnostics - September 29, 2021 Category: Pathology Authors: Anne-Sofie Skou, Kristian L øvvik Juul-Dam, Maria Hansen, Birgitte Lausen, Svea Stratmann, Linda Holmfeldt, Anni Aggerholm, Charlotte Guldborg Nyvold, Hans Beier Ommen, Henrik Hasle Tags: Regular Article Source Type: research