Antiproliferative activity of aqueous and polyphenol-rich extracts of < em > Larrea divaricata < /em > Cav. on a melanoma cell line

The objective of this work was to evaluate the activity of the aqueous extract of Larrea divaricata (Aq), a fraction rich in polyphenols (EA),and the isolated compound quercetin-3-methyl ether (Q3ME) on B16F10 melanoma cells. The effects of Aq, EA and Q3ME were assessed on B16F10 cells by determining the proliferation, viability, apoptosis induction and the expression and phosphorylation of STAT3. The phytochemical composition of the extracts was determined by High Performance Liquid Chromatography. Aq, EA and Q3ME presented antiproliferative activity on B6F10 cells through p-STAT3 inhibition and early and late apoptosis induction (EC50 EA= ≤0.1 µg/ml; Aq= 316 ± 30 µg/ml; Q3ME= <0.1 µg/ml). L. divaricata could be considered for the development of adjuvant phytotherapies in melanoma treatment.PMID:34569365 | DOI:10.1080/14786419.2021.1980789

Source: Natural Product Research - September 27, 2021 Category: Biochemistry Authors: Renzo Martino Mar ía Laura Barreiro Arcos Ignacio Peralta Carla Marrassini Elina Mal én Saint Martin Laura Cogoi Graciela Cremaschi Mar ía Rosario Alonso Claudia Anesini Source Type: research