Functional Outcomes and Their Association With Physical Performance in Mechanically Ventilated Coronavirus Disease 2019 Survivors at 3 Months Following Hospital Discharge: A Cohort Study
OBJECTIVES:
We performed a comprehensive health assessment in mechanically ventilated coronavirus disease 2019 survivors to assess the impact of respiratory and skeletal muscle injury sustained during ICU stay on physical performance at 3 months following hospital discharge.
DESIGN:
Preregistered prospective observational cohort study.
SETTING:
University hospital ICU.
PATIENTS:
All mechanically ventilated coronavirus disease 2019 patients admitted to our ICU during the first European pandemic wave.
MEASUREMENTS AND MAIN RESULTS:
At 3 months after hospital discharge, 46 survivors underwent a comprehensive physical assessment (6-min walking distance, Medical Research Council sum score and handgrip strength), a full pulmonary function test, and a chest CT scan which was used to analyze skeletal muscle architecture. In addition, patient-reported outcomes measures were collected. Physical performance assessed by 6-minute walking distance was below 80% of predicted in 48% of patients. Patients with impaired physical performance had more muscle weakness (Medical Research Council sum score 53 [51–56] vs 59 [56–60]; p
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical investigations Source Type: research
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