Circular RNA hsa_circ_0001598 promotes programmed death-ligand-1-mediated immune escape and trastuzumab resistance via sponging miR-1184 in breast cancer cells

In conclusion, we demonstrate that circ_0001598/miR-1184/PD-L1 signaling plays a crucial role in the regulation of BC progression and trastuzumab-resistance phonotypes, which suggests that circ_0001598 may be a molecular target to treat HER2-positive BC patients.PMID:34559381 | DOI:10.1007/s12026-021-09237-w

Source: Cell Research - September 24, 2021 Category: Cytology Authors: Li Huang Jing Ma Min Cui Source Type: research