Amniotic fluid stem cell administration can prevent epithelial injury from necrotizing enterocolitis

CONCLUSIONS: This study demonstrated that AFSCs and MSCs have different protein release profiles. AFSCs can potentially be used as a preventative strategy for neonates at risk of NEC, while MSCs cannot be used.IMPACT: AFSCs and MSCs have distinct protein secretory profiles, and AFSCs are primarily involved in cell development and growth, while MSCs are involved in immune regulation. AFSCs are unique in transiently enhancing healthy intestinal epithelial cell growth, which offers protection against the development of experimental NEC. The prevention of NEC via the administration of AFSCs should be evaluated in infants at great risk of developing NEC or in infants with early signs of NEC.PMID:34561550 | DOI:10.1038/s41390-021-01657-6

Source: Cell Research - September 25, 2021 Category: Cytology Authors: Bo Li Carol Lee Marissa Cadete Joshua S O'Connell Mashriq Alganabi Dorothy Lee Niloofar Ganji Hiromu Miyake Steven R Botts Kathene C Johnson-Henry Pekka Maattanen Philip M Sherman Agostino Pierro Source Type: research