Polyphenolic Natural Products Active In Silico against SARS-CoV-2 Spike Receptor Binding Domains and Non-Structural Proteins - A Review

The objective of this review is to provide initial data highlighting the utility of polyphenols as potential prophylaxis or treatment for COVID-19. In particular, presented here are virtually screened polyphenolic compounds which showed potential as either antagonists to viral entry and host cell recognition through binding with various receptor-binding regions of SARS-CoV-2 spike protein or as inhibitors of viral replication and post-translational modifications through binding with essential SARS-CoV-2 non-structural proteins.PMID:34533442 | DOI:10.2174/1386207325666210917113207

Source: Combinatorial Chemistry and High Throughput Screening - September 17, 2021 Category: Chemistry Authors: Mark Tristan Quimque Kin Israel Notarte Xela Amor Adviento Mikhail Harvey Cabunoc Von Novi de Leon Felippe Steven Louis Delos Reyes Eiron John Lugtu Joe Anthony Manzano Sofia Nicole Monton John Emmanuel Mu ñoz Katherine Denise Ong Delfin Y ñigo Pilapil Source Type: research