HIF-1 α Pulmonary Phenotype Wide Association Study Unveils a Link to Inflammatory Airway Conditions

We report two SNPs of the HIF1A gene, the intronic rs79865957 and the missense rs41508050. In these positions the A and the T allele are significantly associated with allergic rhinitis and acute bronchitis and bronchiolitis, respectively. These findings further support the role of HIF-1α in inflammatory pulmonary conditions and may serve as a basis to refine our understanding of other HIF-1α associated phenotypes.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research