Beyond Metoclopramide for Gastroparesis

Gastroparesis is characterized by diverse upper gastrointestinal symptoms including nausea, vomiting, early satiety, postprandial fullness, bloating, and upper abdominal pain; slow gastric emptying of solids; and absence of gastric outlet or intestinal obstruction. In clinical practice, diabetes mellitus, and idiopathic and iatrogenic (postsurgical or medication) gastroparesis are the most frequently encountered forms. In addition, diseases affecting the neural control of the upper gut (such as Parkinson ’s disease, or effects of dopaminergic agents), and diseases that damage intrinsic nerves or smooth muscle also cause gastroparesis due to tissue infiltration (such as in scleroderma) or muscle degeneration (as in amyloidosis).
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Here and Now: Clinical Practice Source Type: research