Cortactin and HER2 as potential markers for dural-targeted therapy in advanced gastric cancer

This study retrospectively enrolled 246 patients with stage III GC from January 2015 to December 2016 at our hospital. We explored, using immunostaining techniques, the role of the expression of cortactin and HER2 in the progression of advanced GC. The patient data, including age, sex, cortactin and HER2 expression, pathological parameters and survival, were collected. Univariate and multivariate analyses were used to analyze the characteristics, survival, and prognostic factors of the patients. The results showed that the expression of cortactin was significantly associated with vascular-lymphatic invasion (P <  0.001), N stage (P = 0.001), and TNM stage (P = 0.046). HER2 overexpression correlated with tumor size (P = 0.002), neural invasion (P = 0.002), Lauren classification (P = 0.005) and N stage (P = 0.034). Through univariate analysis using the Kaplan–Meier method, vascular-lymphatic invasion (P = 0.015), neural invasion (P = 0.021), N stage (P <  0.003), and HER2/cortactin co-overexpression (P <  0.028) were shown to be significantly associated with overall survival. Multivariate analysis demonstrated that vascular lymphatic invasion (hazard ratio = 1.481, 95% CI, 1.064 to 2.061,P = 0.020), neural invasion (hazard ratio = 1.505, 95% CI, 1.084 to 2.089,P = 0.015), N stage (N2/N1: hazard ratio = 1.655, 95% CI, 1.048 to 2.641,P <  0.031, N3/N1: hazard ratio = 2.089, 95% CI, 1.325 to 3.29...
Source: Clinical and Experimental Medicine - Category: Research Source Type: research