Phenylpropanoid-conjugated iridoid glucosides from leaves of Morinda morindoides

AbstractThree phenylpropanoid-conjugated iridoid glucosides, acetylgaertneric acid (1), acetyldehydrogaertneroside (2), and dehydrogaertneric acid (10), together with nine known related iridoid glucosides (3–9,11, and12), two coumaroyl alkaloids, one benzenoid, and three flavonoid glucosides were isolated from leaves ofMorinda morindoides (Rubiaceae). Structures of these isolated compounds were determined using spectroscopic analysis. Compounds1–18 and previously isolated compounds (19–29) were evaluated for anti-trypanosomal activity againstTrypanosoma cruzi Tulahuen strain (trypomastigote and amastigote) together with cytotoxicity against host cells, new-born mouse heart cells. Among them, molucidin (21) and prismatomerin (22) exhibited good anti-trypanosomal activity (IC50 of 4.67 and 5.70  µM, respectively), together with cytotoxicity (CC50 of 2.76 and 3.22  μM, respectively). Compounds1–18 did not show anti-malarial activity against a chloroquine/mefloquine-sensitive strain ofPlasmodium falciparum.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research