Double PIK3CA Alterations and Parallel Evolution in Colorectal Cancers

CONCLUSIONS: The findings supported multiclonal CRCs resulting from parallel evolution during the progression from adenoma to adenocarcinoma within the mitogen-activated protein kinase pathway, as previously demonstrated, or the mammalian target of rapamycin pathway. Further studies are warranted to elucidate clinical significance and potential targeted therapy for CRC patients with double PIK3CA alterations and impacts on clinical decision-making in patients with multiclonal CRCs harboring divergent PIK3CA mutational status.PMID:34519764 | DOI:10.1093/ajcp/aqab119

Source: Clinical Colorectal Cancer - September 14, 2021 Category: Cancer & Oncology Authors: Ming-Tseh Lin Gang Zheng Erika Rodriguez Li-Hui Tseng Vamsi Parini Rena Xian Ying Zou Christopher D Gocke James R Eshleman Source Type: research