Plasma levels of amino acids and derivatives in retinopathy of prematurity

Conclusion: The plasma levels of citrulline, creatinine, arginine, and aminoadipic acid were significantly changed in ROP patients. These metabolites could be considered potential biomarkers of ROP, and their related metabolic pathways might be involved in ROP pathogenesis.PMID:34522185 | PMC:PMC8436098 | DOI:10.7150/ijms.63603
Source: International Journal of Medical Sciences - Category: Biomedical Science Authors: Source Type: research

Related Links:

Attention is limited, both in processing capacity (leading to phenomena of "inattentional blindness") and in the capacity for selective focus (leading to distraction). Load theory (e.g., Lavie, 1995) accounts for both limitations by proposing that perceptu...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
Ann Med Surg (Lond). 2021 Oct 1;70:102904. doi: 10.1016/j.amsu.2021.102904. eCollection 2021 Oct.ABSTRACTINTRODUCTION: Diabetic retinopathy (DR) increases the risk of blindness by 25 times. Advanced researchs are justified for better management, leading to the role of Optical Coherence Tomography-Angiography (OCT-A), a new non-invasive imaging technique exploring retinal vascularization.Our purpose is to identify microvascular macular anomalies of DR on OCT-A with qualitative and quantitative evaluation of their impact on retinal vascularization.PATIENTS AND METHODS: This is a descriptive cross-sectional study where 120 ey...
Source: Annals of Medicine - Category: Internal Medicine Authors: Source Type: research
Biochem Biophys Res Commun. 2021 Oct 16;582:100-104. doi: 10.1016/j.bbrc.2021.10.036. Online ahead of print.ABSTRACTAniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function. Most of the patients suffer from aniridia-related keratopathy, a progressive opacification of the cornea. There is no effective treatment for this blinding disease. Here we screen for small compounds and identified Ritanserin, a serotonin 2A receptor antagonist, that can rescue PAX6 haploinsufficiency of mutan...
Source: Cell Research - Category: Cytology Authors: Source Type: research
A Raleigh-based gene therapy startup that's tackling blindness has filled two leadership roles shortly after raising $19 million in seed financing.
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
CONCLUSION: We propose intermediate IFS as a new subgroup of patients with IFS who do not fit into the standard classification of aIFS or cIFS.PMID:34694144 | DOI:10.1177/00034894211052854
Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Source Type: research
CONCLUSIONS: Results of our study support the hypothesis that D-allele and DD-genotype of rs35569394 have deleterious effect on the progression of DR. C-allele had skewed frequency towards DR III subjects owing to strong linkage disequilibrium between C-allele (rs699947) and D-allele (rs35569394).PMID:34693874 | DOI:10.1080/13816810.2021.1992786
Source: Ophthalmic Genetics - Category: Opthalmology Authors: Source Type: research
J Immunol Res. 2021 Oct 14;2021:2389029. doi: 10.1155/2021/2389029. eCollection 2021.ABSTRACTDiabetic retinopathy (DR), as a major cause of blindness worldwide, is one common complication of diabetes mellitus. Inflammatory response and oxidative stress injury of endothelial cells play significant roles in the pathogenesis of DR. The study is aimed at investigating the effects of lysophosphatidylcholine (LPC) on the dysfunction of high glucose- (HG-) treated human retinal microvascular endothelial cells (HRMECs) after being cocultured with bone marrow mesenchymal stem cells (BMSCs) and the underlying regulatory mechanism. C...
Source: Journal of Immunology Research - Category: Allergy & Immunology Authors: Source Type: research
Free Radic Biol Med. 2021 Oct 22;177:100-119. doi: 10.1016/j.freeradbiomed.2021.10.027. Online ahead of print.ABSTRACTCataract and glaucoma are the major causes of severe visual loss and blindness in older adults. This review article describes the currently available basic and clinical evidence regarding vitamin E protection against these eye diseases in the chronologic order of the publications. Experimental evidence has suggested both that oxidative stress due to the accumulation of free radicals plays a role in the pathogenesis of cataracts and glaucoma and that the process can be prevented or ameliorated by vitamin E. ...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Source Type: research
CONCLUSION: We propose intermediate IFS as a new subgroup of patients with IFS who do not fit into the standard classification of aIFS or cIFS.PMID:34694144 | DOI:10.1177/00034894211052854
Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Source Type: research
J Immunol Res. 2021 Oct 14;2021:2389029. doi: 10.1155/2021/2389029. eCollection 2021.ABSTRACTDiabetic retinopathy (DR), as a major cause of blindness worldwide, is one common complication of diabetes mellitus. Inflammatory response and oxidative stress injury of endothelial cells play significant roles in the pathogenesis of DR. The study is aimed at investigating the effects of lysophosphatidylcholine (LPC) on the dysfunction of high glucose- (HG-) treated human retinal microvascular endothelial cells (HRMECs) after being cocultured with bone marrow mesenchymal stem cells (BMSCs) and the underlying regulatory mechanism. C...
Source: Journal of Immunology Research - Category: Allergy & Immunology Authors: Source Type: research
More News: Biomedical Science | Blindness | Opthalmology | Study | Vitamin A