Obstructive sleep apneas naturally occur in mice during rem sleep and are highly prevalent in a mouse model of down syndrome

CONCLUSIONS: Mice physiologically exhibit both CSAs and OSAs. The latter appear almost exclusively during REMS, and are highly prevalent in Ts65Dn. Mice may, thus, represent a useful model to accelerate the understanding of the pathophysiology and genetics of sleep-disordered breathing and to help the development of new therapies.PMID:34509609 | DOI:10.1016/j.nbd.2021.105508

Source: Neurobiology of Disease - September 12, 2021 Category: Neurology Authors: Maria Lavinia Bartolucci Chiara Berteotti Sara Alvente Stefano Bastianini Sandra Guidi Viviana Lo Martire Gabriele Matteoli Alessandro Silvani Fiorenza Stagni Marcello Bosi Giulio Alessandri-Bonetti Renata Bartesaghi Giovanna Zoccoli Source Type: research