14-year trends and resistance patterns of blood and cerebrospinal fluid cultures in children under three years old

Bacterial sepsis is a leading cause of morbidity and mortality in young infants accounting for approximately 6% of neonatal deaths worldwide, but its management is threatened by rising antimicrobial resistance (AMR). 1 2 Resistance in Gram-negative bacteria is particularly concerning, with increasing multi-drug resistance and evidence that poor empirical therapy choice can result in poor prognosis. 3 4 Improved surveillance is highlighted as one of the key recommendations to counter AMR in the World Health Organization's global action plan on antimicrobial resistance, and also in the 5-year antimicrobial resistance strategy of the United Kingdom (UK) Department of Health.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research