PPAR γ signaling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transition

CONCLUSIONS: A cyclophosphamide metabolite alone suffices to damage and deplete human scalp eHFSCs by promoting apoptosis, DNA damage, and EMT ex vivo. Therefore, pCIA-therapeutic strategies need to target these pathological processes. Our data introduce the stimulation of PPARγ signaling as a novel intervention strategy for the prevention of pCIA, given the ability of NAGED to prevent chemotherapy-induced eHFSCs damage ex vivo.PMID:34496034 | DOI:10.1111/bjd.20745

Source: The British Journal of Dermatology - September 8, 2021 Category: Dermatology Authors: I Piccini L Brunken J Ch éret S Ghatak Y Ramot M Alam T S Purba J Hardman H Erdmann F Jimenez R Paus M Bertolini Source Type: research