A Randomized Trial of Antimicrobial Duration for Cystic Fibrosis Pulmonary Exacerbation Treatment

CONCLUSIONS: Among CF adults with early treatment improvement during exacerbation, ppFEV1 after 10-days of intravenous antimicrobials is not inferior to 14-days. For those with less improvement after one week, 21-days is not superior to 14-days. Clinical trial registration available at www.clinicaltrials.gov, ID: NCT02781610.PMID:34469706 | DOI:10.1164/rccm.202102-0461OC

Source: Am J Respir Crit Car... - September 1, 2021 Category: Intensive Care Authors: Christopher H Goss Sonya L Heltshe Natalie E West Michelle Skalland Don B Sanders Raksha Jain Tara L Barto Barbra Fogarty Bruce C Marshall Donald R VanDevanter Patrick A Flume STOP2 Investigators Source Type: research