Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients

In conclusion, we demonstrated the feasibility and safety of ACT with multimer-sorted Melan-A and MELOE-1 specific T cells to metastatic melanoma patients. The clinical efficacy of such therapeutic strategy could be further enhanced by the selection of highly reactive T-cells, based on PD-1 and TIGIT co-expression, and a combination with ICI, such as anti-PD-1.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research