Genomic progression of precancerous actinic keratosis to squamous cell carcinoma
The mechanism underlying the progression of actinic keratosis (AK) and cutaneous squamous cell carcinoma in situ (SCCIS) to squamous cell carcinoma (SCC) remains unclear. To investigate this, we performed regional microdissection and targeted deep sequencing in SCC (N=10) and paired adjacent SE (sun-damaged epidermis)/AK/SCCIS (N=13) samples to detect mutations and copy number alterations (CNAs). Most (11/13) SE/AK/SCCIS tissues harbored ≥ 1 driver alterations, indicating their precancerous nature.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Yoon-Seob Kim, Sun Shin, Seung-Hyun Jung, Young Min Park, Gyeong Sin Park, Sug Hyung Lee, Yeun-Jun Chung Tags: Original Article Source Type: research
More News: Cancer & Oncology | Carcinoma | Carcinoma in Situ | Dermatology | Skin | Skin Cancer | Squamous Cell Carcinoma