Peas in the Pod: Systemic Therapy for Systemic Disease, Radiation for Local Disease

I would initiate systemic therapy (TPF) with docetaxel, cisplatin, and fluorouracil (FU) to treat known sites of disease in addition to unidentified distant metastases that are likely present.1 After 3 cycles of TPF, obtain a positron emission tomography. An alternative to TPF is pembrolizumab combined with carboplatin alone or with FU. If the patient has a complete or partial metabolic response, treat local-regional disease to 66 Gy in 33 once-daily fractions using an ipsilateral field arrangement if the tonsil cancer is well lateralized.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research