Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan

The evolution of drug resistance is one of the biggest challenges in leishmaniasis and has prompted the need for new antileishmanial drugs. Repurposing of approved drugs is a faster and very attractive strateg...

Source: Parasites and Vectors - August 28, 2021 Category: Microbiology Authors: Chlo é Rosa-Teijeiro, Victoria Wagner, Audrey Corbeil, Ilda d’Annessa, Philippe Leprohon, Rubens L. do Monte-Neto and Christopher Fernandez-Prada Tags: Research Source Type: research