Children with Down syndrome: association of Bcl-I polymorphism of nuclear receptor subfamily 3 group C member 1 gene with obesity

CONCLUSIONS: Our study found a weak association of the G allele of Bcl-I rs41423247 with the presence of obesity among normal Egyptian children, while there was a significant association of the mutant C allele of the Bcl-I rs41423247 with Down syndrome, suggesting a possible association with Down syndrome pathophysiology.IMPACT: Bcl-I polymorphism is not strikingly associated with obesity in normal children. The GG genotype is higher in obese normal children but without significant difference. The significant increase of the mutant C allele in Down-children than normal children. This may be relevant to Down syndrome's pathophysiology which disturbs the whole genome's balance.PMID:34433889 | DOI:10.1038/s41390-021-01711-3

Source: Pediatric Research - August 26, 2021 Category: Pediatrics Authors: Wafaa Moustafa M Abo El-Fotoh Hebatallah Mohammed Nasser Bahbah Manal Abd El-Monem Elaithy Rana Khairy Rashad Ahmed Noha Rabie Bayomy Source Type: research