Cancers, Vol. 13, Pages 4239: CD200 Baseline Serum Levels Predict Prognosis of Chronic Lymphocytic Leukemia

Cancers, Vol. 13, Pages 4239: CD200 Baseline Serum Levels Predict Prognosis of Chronic Lymphocytic Leukemia Cancers doi: 10.3390/cancers13164239 Authors: D’Arena Vitale Coscia Lamorte Pietrantuono Perutelli D’Auria Statuto Valvano Tomasso Griggio Jones Mansueto Villani D’Agostino Viglioglia Feo Calapai Mannucci Sgambato Efremov Laurenti Membrane-bound CD200 is overexpressed in chronic lymphocytic leukemia (CLL), and there is some evidence that its soluble ectodomain (sCD200) could also be involved in the pathophysiology and the disease. However, very little is known about sCD200’s prognostic significance. sCD200 was tested at diagnosis in 272 patients with CLL and in 78 age- and sex-matched healthy subjects using a specific human CD200 (OX-2 membrane glycoprotein) ELISA kit. A significantly higher concentration of sCD200 was found in CLL patients compared to controls. In our cohort, sCD200 was significantly higher in patients who were older than 66 years, with Binet stage C, unmutated IgVH and unfavorable (del11q or del17p) FISH. Time-to-first treatment and overall survival were significantly shorter in patients with higher sCD200 concentration, using as a cut-off 1281 pg/mL, the median value for sCD200 concentration in the whole CLL cohort. However, the prognostic impact of sCD200 was not confirmed in multivariate analysis. Baseline sCD200 values appeared to have an impact on the response to chem...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research