P –102 GM-CSF (granulocyte-macrophage colony-stimulating factor) as a sperm medium supplement improves sperm quality in Oligoastenoteratospermia (OAT) men by activating the PI3K/Akt pathway

This study needs further investigations, including Real-time PCR for the genes of this signaling pathway which is ongoing.Wider implications of the findings: We showed for the first time that GM-CSF can improve sperm quality by influencing motility and energy metabolism in spermatozoa which can be affected by increasing the phosphorylation of AKT. This growth factor could be an appropriate supplement in sperm media for OAT patients.Trial registration numberIRCT20200519047508N1
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research