P-646 Pregnancy outcomes in women with panhypopituitarism - A population-based study

AbstractStudy questionWhat are the consequences of panhypopituitarism on pregnancy outcomes?Summary answerAfter controlling for confounding effects, women with panhypopituitarism have a higher prevalence of adverse obstetrical (including post-partum hemorrhage, hysterectomy and maternal death) and neonatal outcomes.What is known alreadyPanhypopituitarism is a condition of inadequate or absent anterior pituitary hormone production. Pregnancy in women with panhypopituitarism is uncommon and there is only limited data (mainly case reports) regarding pregnancy outcomes in these women. Given the scarcity of data we sought to assess the association between panhypopituitarism and obstetrical and neonatal outcomes.Study design, size, durationA retrospective population-based study utilizing data from the Healthcare Cost and Utilization Project —Nationwide Inpatient Sample (HCUP-NIS). A dataset of all deliveries between 2004 and 2014 inclusively, was created. Within this group, all deliveries to women who had a diagnosis of panhypopituitarism during pregnancy were identified as part of the study group (n = 179), and the remaining del iveries comprised the reference group (n = 9,096,609).Participants/materials, setting, methodsThe HCUP-NIS is the largest inpatient sample database in the USA, and it is comprised of hospitalizations throughout the country. It provides information relating to 20% of US admissions and represents over 96% of the American population. Multivariate lo...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research