O-236 The clinical and morphokinetic factors indicating a risk of pregnancy loss after a euploid embryo transfer

AbstractStudy questionAre there any clinical and morphokinetic factors which may affect the pregnancy outcome after a euploid embryo transfer?Summary answerBody mass index (BMI), endometriosis, the history of recurrent pregnancy losses and the number of previous frozen-thawed unsuccessful embryo transfer (FET) cycles impact pregnancy outcomes.What is known alreadyPreimplantation genetic testing for aneuploidy (PGT-A) is largely used for various indications to detect chromosomal abnormalities in assisted reproductive technologies (ART). The most common reason for the first trimester pregnancy losses is chromosomal abnormalities. However, the factors that cause pregnancy loss after a euploid embryo transfer are not fully understood.Study design, size, durationThe pregnancy results of all single euploid embryos tested with next generation sequencing (NGS) in Istanbul Memorial Hospital between January 2017 and March 2020 were evaluated in this single center retrospective cohort study. The cases that resulted in pregnancy below the age of 43 were analyzed according to outcomes; biochemical pregnancy loss (Group 1), clinical pregnancy loss (Group 2) and live birth (Group 3).Participants/materials, setting, methodsThe transfer of 2041 single euploid embryos resulted in 1492 pregnancies. The clinical and morphokinetic parameters observed using time lapse imaging (TLI) were compared among the three groups.Main results and the role of chanceThe overall pregnancy rate was 73.1%, the rat...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research