O-073 Perinatal outcomes of infants conceived using partner versus donor sperm - An analysis of singleton and twin pregnancies from the UK national dataset

AbstractStudy questionAre perinatal outcomes different in pregnancies conceived using donor sperm compared with those with partner sperm?Summary answerThe perinatal outcomes of singleton and twin pregnancies conceived with donor sperm are better when compared to those conceived with partner spermWhat is known alreadyThere has been a substantial increase in the use of donor sperm in the last 15 years across the world. A recent systematic review and meta-analysis has suggested that there is an increased risk of hypertensive disorders of pregnancy and small for gestational age babies from ART treatment using donor sperm compared to partner`s sperm. This meta-analysis was limited due to poor quality of primary studies often with small sample sizes.Study design, size, durationThis is a retrospective cohort study on 196,293 singleton and 46,275 twin pregnancies from the Human Fertilisation and Embryology Authority (HFEA) anonymised dataset including all live births from 1991 to 2016. Outcomes were preterm birth (< 37 weeks); very preterm birth (< 32 weeks); very low, low, high and very high birth weight (< 1500g,< 2500g,>4000g and>4500g respectively); congenital anomaly and healthy baby (term live birth with appropriate weight and no congenital anomaly).Participants/materials, setting, methodsAll pregnancies resulting in singleton or twin livebirth were included. Any cycle involving donor oocytes, PGD, gamete intra-fallopian transfer, ectopic pregnancy, miscarriag...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research