O-207 Which infertile patients mostly deserve to have a sperm DNA fragmentation index done? Findings from a cross-sectional study

AbstractStudy questionCurrent scientific guidelines do not clearly suggest which patients would benefit the most from a sperm DNA fragmentation (SDF) test.Summary answerWe aimed to investigate potential predictive factors for altered SDF in a homogenous cohort of white-European men presenting for primary couple ’s infertility.What is known alreadyHigh SDF has been associated with reduced fertilization rates, reduced chances of natural conception and an increased risk of early pregnancy loss.Study design, size, durationData from 478 consecutive men with normal or altered SDF were analysed. Infertility was defined according to the WHO criteria. Semen analysis, SDF (according to SCSA) and serum hormones were measured in every patient. Health significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Altered SDF was considered with a threshold of  >  30%.Participants/materials, setting, methodsDescriptive statistics compared the overall characteristics of patients with normal SDF and altered SDF. Logistic regression analysis tested potential predictors of altered SDF. ROC curve was used to test the accuracy of the model in predicting SDF alterationMain results and the role of chanceOf 478 patients, 253 (57.7%) had altered SDF. Median (IQR) age and BMI of the whole cohort were 38 (35-42) years and 25.1 (23.3-27.1) kg/m2 respectively. Patients with altered SDF were older (median (IQR) age: 39 (36-43) vs. 37 (34-38) years, p  <  0.0001), had low...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research