P –707 Does the dose or type of gonadotropin affect the reproductive outcomes of poor responders undergoing modified natural cycle IVF (MNC-IVF)?

AbstractStudy questionDoes the dose or type of gonadotropin affect the reproductive outcomes of poor responders undergoing MNC-IVF?Summary answerNeither the type nor the dose of gonadotropins affects the reproductive outcomes of poor responders undergoing MNC-IVF.What is known alreadyPoor ovarian response (POR) to ovarian stimulation remains a major therapeutic challenge in routine IVF practice, because of the association with low live birth rates and high cancellation rates. Although high doses of gonadotropins are traditionally used to stimulate the ovaries in women with predicted POR, MNC-IVF has been proposed as a mild-approach alternative in this population. Typically, the MNC protocol includes GnRH-antagonists to avoid premature ovulation and gonadotropin add-back stimulation at the late follicular phase. However, evidence is sparse, and there is no consensus regarding a specific dose or type of gonadotropins in this mild stimulation protocol.Study design, size, durationThis is a retrospective cohort study including patients attending a tertiary referral University Hospital from 1st January 2017 until 1st March 2020.Participants/materials, setting, methodsAll women who underwent MNC-IVF in our center were included. Gonadotropins [recombinant FSH (rFSH), urinary FSH (uFSH) or highly purified human menopausal gonadotrophin (hp-hMG)] were started when a follicle with a mean diameter of 12 –14 mm was observed on ultrasound scan, followed by GnRH antagonists (0.25mg/day)...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research