Immune-related genes STIM1, ITPKC and PELI1 polymorphisms are associated with risk of colorectal cancer

Objectives STIM1, ITPKC and PELI1 are all immune-related genes that take part in the T cell activation, toll-like receptor and IL1 receptor pathways. The goal of this study was to evaluate the associations between STIM1, ITPKC and PELI1 polymorphisms and colorectal cancer (CRC) risk. Methods Six single nucleotide polymorphisms (SNPs) in STIM1, ITPKC and PELI1 were genotyped using a MassARRAY platform in a discovery cohort including 480 CRC cases and 480 healthy individuals and validated in a replication cohort including 505 CRC cases and 510 controls. Results The minor alleles of rs3794050, rs3750996 and rs2607420 were associated with an increased CRC risk (P 
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Gastrointestinal Cancer Source Type: research