The effect of exchange transfusion on mortality in neonatal sepsis: a meta-analysis

Conclusion: Currently, the use of ET in neonatal sepsis is not directly recommended due to low certainty of evidence, inadequate power and moderate –high risk of bias and heterogeneity.Trial registration: PROSPERO (CRD42020176629) (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=176629)What is Known:• Exchange transfusion is one of the adjunctive methods for treatment of neonatal sepsis.What is New:• The pooled analysis of all studies shows that exchange transfusion has a low certainty of evidence in the context of neonatal mortality. However, at this point, this intervention cannot be refuted or recommended due to heterogeneity of studies and inadequate power.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research